What are Hydrogenases? (part 7)

 Hydrogenases are enzymes that can reversibly split molecular hydrogen to produce atomic hydrogen.

It is believed that we apparently have such hydrogenases in our bodies. Incidentally, all living organisms on this earth, both plant and animal, are termed "DNA oraganisms." This means that all living organisms on the earth share common ancestor. I will now write about our ancestor born 3.8 billion years ago.

In 1997,an article called "Biological Activition of Hydrogen " by R.P.Happe of Amsterdam University was submitted in the English Journal" "Nature", Vol. 385,pp 126,'97. The main thrust of this article is as follows. Hydrogenases are enzymes that can reversibly split molecular hydrogen. ...... the crystal structure of a Ni/Fe hydrogenase (from the bacterium Desulfovibrio gigas) was reported. ...... Ni/Fe hydrogenases are among the oldest enzymes (3.8 billion years old) , demonstrating that early life forms had developed an effective way to activate molecular hydrogen at ambient temperature and pH....... .

My own explanation of this article is as follows.

It is active oxygen that threatens the survival of living organisms. For living organisms to survive, it was necessary to develop a mechanism for scavenging active oxygen. The best way to scavenge active oxygen is by means of atomic (active) hydrogen. To produce atomic (active) hydrogen, it is necessary to split molecular hydrogen. The hydrogenase developed by bacteria 3.8 billion years ago, an enzyme that split molecular to produce atomic hydrogen.

We have seen, then. that to ensure their own survival, it was necessary for living organisms to achieve the ability to produce active hydrogen in order to scavenge active oxygen ; hydrogenase developed by the oldest bacteria 3.8 billion years old was one of theses enzymes. Moreover, we may consider that this hydrogenase was the ancestor found in the bodies of higher creatures including ourselves.

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